Omaha, Nebraska 68198


Purpose:

The purpose of this study is to compare the efficacy of oral N-acetylcysteine and intravenous sodium bicarbonate for the prevention of CIN after cardiac catheterization.


Study summary:

It is thought that N-acetylcysteine may reduce the ability of generated oxygen free radicals to damage cells by scavenging them. N-acetylcysteine may also increase the biologic effects of nitric oxide by combining with nitric oxide to form S-nitrosothiol, a more stable form and potent vasodilator. It also increases the expression of nitric oxide synthesis and may improve blood flow. Oxidants activate a signal-transduction cascade and molecular response that may initiate the cell-death pathway. These pathways seem to be sensitive to the redox state of the cell and are inhibited by N-acetylcysteine, which promotes pathways that lead to repair and survival whenever cells are under oxidant stress.


Criteria:

Inclusion Criteria: 19 years of age - Baseline serum creatinine or - Calculated creatinine - Stable Renal Function - Left Ventricular ejection fraction - Non-pregnant, non-lactating females (all women of childbearing potential must have a negative serum pregnancy test. No contraception will be required - Able to sign informed consent Exclusion Criteria: - Acute renal failure - History of Kidney transplant - Currently receiving N-acetylcysteine _ Contraindication of hypersensitivity to N-acetylcysteine or sodium bicarbonate - Left ventricular ejection fraction - Pregnant, lactating females - Allergy to contrast dye


NCT ID:

NCT00579995


Primary Contact:

Principal Investigator
Scott Shurmur, MD
University of Nebraska


Backup Contact:

N/A


Location Contact:

Omaha, Nebraska 68198
United States

Scott Shurmur, MD
Phone: 402-559-5151
Email: sshurmur@unmc.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: January 16, 2018

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