The purpose of this study is to better understand the genetic causes of cancer and the
inherited tendency to develop cancer. To accomplish this, blood specimens and/or saliva
samples and/or tumor and normal tissue blocks from patients and families of patients with
cancer will be collected. Blood specimens will be frozen and stored for analysis at a later
date. Tumor tissue and normal tissue will be stored for analysis at a later date. In order to
perform this study, patients and members of their families will be asked to provide blood
samples and/or saliva samples. Individuals will be asked to provide a history of cancer in
their relatives at the time the blood sample is given. No relatives will be contacted before
they have been asked by a family member if they wish to participate in this study. If they do
wish to participate, the relatives should indicate this by returning the "Family Member
Consent for Contact Form" After we receive this form, arrangements may be made for the family
member to send in a blood and/or saliva sample or to come in person to provide the sample to
Except for family history, no medical information provided by one member of a family will be
discussed with other family members. At the end of this form, we will also ask for your
permission to be contacted in the future to discuss information about your health, additional
research with your samples and/or certain research findings possibly related to your sample.
Patients can provide either a blood or saliva sample for the protocol. For blood samples, two
tubes of blood (approximately 20 cc) will be drawn from the patient, utilizing a sterile
technique. The tubes will be rocked so as to mix the blood with the additive (EDTA) in the
tubes. For saliva samples, approximately 2-4 ml of saliva will be collected in specialized
Oragene DNA Self-Collection Kit tubes. The sample(s) may also be used to detect new genes or
changes in genes that may tell us who is at risk for certain types of cancer and/or other
- Patients accepted for referral to the Cancer Family Clinic of the Department of
Medicine at Memorial Sloan-Kettering Cancer Center are eligible for participation in
this study. Such patients should have a history of cancers of the breast, ovary,
colon, prostate, uterus, non-Hodgkin's lymphoma, leukemia, soft tissue sarcoma,
endocrine neoplasms, or other malignancies presenting in first degree relatives or in
successive generations as part of a suspected cancer family syndrome.
- Family members of probands including parents, sisters, brothers, half-brothers and
sisters, sons, daughters, grandparents, as well as aunts and uncles are also eligible.
- This study involves research which presents no greater than minimal risk to children.
The assent of any minor should be obtained before the patient is entered into this