Expired Study
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Omaha, Nebraska 68198


Purpose:

RATIONALE: Diagnostic procedures, such as cardiac magnetic resonance imaging, may help doctors detect early changes in the heart caused by chemotherapy. PURPOSE: This clinical trial is studying how well cardiac magnetic resonance imaging works in patients with newly diagnosed non-Hodgkin lymphoma or Hodgkin lymphoma receiving doxorubicin.


Study summary:

OBJECTIVES: - To determine whether early myocardial structural and functional changes can be detected using cardiac MRI in patients with newly diagnosed non-Hodgkin lymphoma or Hodgkin lymphoma receiving doxorubicin hydrochloride-based chemotherapy. OUTLINE: Patients undergo cardiac MRI with gadolinium contrast prior to initiation of doxorubicin hydrochloride-based chemotherapy and 3 months after completion of six courses of chemotherapy for non-Hodgkin lymphoma and twelve courses of chemotherapy for Hodgkin lymphoma.


Criteria:

DISEASE CHARACTERISTICS: - Diagnosis of non-Hodgkin lymphoma or Hodgkin lymphoma - Newly diagnosed disease - Planning to receive doxorubicin hydrochloride-based chemotherapy solely at the University of Nebraska Medical Center PATIENT CHARACTERISTICS: - Not pregnant or nursing - Fertile patients must use effective contraception - No pacemaker - No chronic kidney disease stages 3-5 (glomerular filtration rate < 60 mL/min) - Able to lie flat for 90 minutes - No metallic foreign body not approved for MRI - No known hypersensitivity to gadolinium contrast or other required drugs in the study - No comorbidity or condition which, in the opinion of the investigator, may interfere with the assessments and procedures of this study - Able to fulfill the requirements of the study PRIOR CONCURRENT THERAPY: - See Disease Characteristics - No prior chemotherapy - No prior radiotherapy to mantle or mediastinum


NCT ID:

NCT00577798


Primary Contact:

Principal Investigator
Thomas R. Porter, M.D.
University of Nebraska


Backup Contact:

N/A


Location Contact:

Omaha, Nebraska 68198
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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