This randomized phase III trial is studying Flexitouch® home maintenance therapy to see how
well it works compared with standard home maintenance therapy in treating patients with
lower-extremity lymphedema caused by treatment for cervical cancer, vulvar cancer, or
endometrial cancer. Flexitouch® home maintenance therapy may lessen lower-extremity
lymphedema caused by treatment for gynecologic cancer. It is not yet known whether the
Flexitouch® system is more effective than standard home maintenance therapy in treating
I. Compare the effectiveness of the Flexitouch® System to standard home lymphedema therapy
(Manual Lymphatic Drainage) in the management of lower-extremity lymphedema in women with a
history of cervical, vulvar, or endometrial cancer.
I. Compare the quality of life (QOL) and functional status between patients using the
Flexitouch® System and those following standard home lymphedema treatment (Manual Lymphatic
Drainage) programs in the management of lower-extremity lymphedema
OUTLINE: This is a multicenter study. Patients are stratified according to site of cancer
(cervical vs vulvar vs endometrial) and stage of lymphedema at diagnosis. Patients are
randomized to 1 of 2 treatment arms.
ARM I: Patients receive standard home maintenance therapy and perform self-manual lymphatic
drainage once daily for 60 minutes for 24 weeks.
ARM II: Patients receive Flexitouch® home maintenance therapy once daily for 60 minutes for
Clinical staff measure patients' lower limb (both) volumes and patients complete quality of
life questionnaires at baseline, every 8 weeks during treatment, and at completion of study
- Has lower-extremity lymphedema on one side of the body caused by surgery,
chemotherapy, and/or radiation therapy.
- At least 6 months since clinic therapy for lower-extremity lymphedema
- Is within 3 years from finishing cancer treatment
- No active or recurrent cancer
- More than 3 months since cancer treatment