The purpose of the study was to determine the effect of Epoetin alfa therapy (short term
versus long term) with and without a home-based individualized exercise program that
incorporated aerobic and strength resistance training for patients being treated with
high-dose chemotherapy and autologous peripheral bloodstem cell transplantation (PBSC T) for
multiple myeloma. The endpoints for the study included the number of attempts at and total
number of days of stem cell collection, number of RBC and platelet transfusions during the
transplantation period, time-to-recovery after transplantation, and response to intensive
therapy for multiple myeloma.
- Those who were not at high risk for impending pathologic fracture or cord
compression, as determined by magnetic resonance imaging and other radiology reports
and physician assessments,and enrolled in Total Therapy treatment protocols were
invited to participate in the study.
Patients were excluded if they showed any of the following attributes/conditions:
- Inability to understand the intent of the study
- Current diagnosis with a major psychiatric illness
- Presence of microcytic or macrocytic anemia
- Uncontrolled hypertension
- Red cell transfusions within 2 weeks; and
- Recombinant epoetin alfa within 8 weeks of study enrollment.