The purpose of this study is to prospectively analyze and compare conventional stress
echocardiograms and real-time myocardial contrast stress echocardiograms; and to determine
the effect of contrast agents used during real-time myocardial contrast stress
echocardiograms on serum troponin I levels.
To compare two different stress echocardiograms (conventional Stress echocardiograms or
Real-time Myocardial Contrast Stress Echocardiograms) that are in routine clinical use. The
information, including the digital images that are collected during the stress tests is used
to determine if the usse of specialized imaging techniques and ultrasound contrast can
better detect blockage in blood flow to the heart and predict how patients outcome may be
affected by this detection of a blockage.
- Male or female
- Age > 19 years
- Scheduled for a stress echocardiography
- Are conscious and coherent, and able to communicate effectively with trial personnel
- For troponin evaluation, only hospitalized patients who had a troponin level drawn in
the morning of and prior to stress echocardiogram will be included.
- Pregnant and breast feeding women are excluded from participation because of the
possibility of a bias as CSE is routinely used in pregnant patients secondary to lack
of human studies to determine the fetal risk of use of Definity.
- Age < 19 years old
- Known or suspected hypersensitivity to ultrasound contrast agents or other drugs
used for the study
- Possibility that potential subject may be pregnant
- Studies where RT-MCE was specifically requested by the ordering physician