Expired Study
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Little Rock, Arkansas 72202


Purpose:

Type I diabetes (T1DM) is the second most common chronic illness effecting children in the USA. Worldwide, Type I diabetes is increasing in incidence, and its underlying etiology remains elusive. Nevertheless, recent data supports the notion that early and intensive management of Type I diabetes can 1) decrease long-term complications of diabetes; and 2) may significantly improve beta cell function and insulin secretion over ensuing years. To this end, we propose using insulin pump therapy to preserve and/or enhance residual endogenous B-cell secretory capacity among patients with newly diagnosed Type 1 DM. Furthermore, we anticipate that early use of an insulin pump will improve glycemic control beyond that achieved with standard multiple daily injection (MDI) therapy, and will be well-tolerated by the patient. These data will provide important pilot information to explore the potential role of intensive insulin pump therapy in the treatment of children newly diagnosed with Type I diabetes. The specific aim of this study is to test the following hypothesis: Early use of insulin pump therapy is effective in preserving or enhancing residual endogenous pancreatic B-cell secretory capacity among patients with newly diagnosed T1DM: Moreover, early use of an insulin pump will improve glycemic control beyond that achieved with standard multiple injection therapy, and will be well-tolerated by the patient.


Criteria:

Inclusion Criteria: - Medical history and clinical presentation consistent with the diagnosis of Type 1 DM. - Age: 8-18 years Exclusion Criteria: - Clinical presentation consistent with Type 2 DM. - History of other chronic systemic inflammatory or autoimmune disease or other severe medical conditions. - Concurrent pregnancy. - Participation in other research protocols or use of other investigational agents within 30 days of enrollment.


NCT ID:

NCT00574405


Primary Contact:

Principal Investigator
Kathryn M Thrailkill, MD
Arkansas Children's Hospital Research Institute


Backup Contact:

N/A


Location Contact:

Little Rock, Arkansas 72202
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 19, 2017

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