Expired Study
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Nashville, Tennessee 37232


Purpose:

We plan to study the concept of "energy starvation" in heart failure by evaluation of patients with nonischemic dilated cardiomyopathy (NIDCM) (heart failure with reduced heart pump function due to causes other than heart attack). We will use a combination of positron emission tomography and magnetic resonance imaging to study metabolism, anatomy, function, blood flow and efficiency, before and after 6 months' treatment with the drug spironolactone which blocks the deleterious effects of the hormone aldosterone on the myocardium (heart muscle).


Study summary:

Preliminary results showed reduced subendocardial myocardial perfusion reserve in NIDCM compared to normal subjects, and that the degree of impaired perfusion reserve was related to the oxidative metabolic rate as measured by positron emission tomography.


Criteria:

Inclusion Criteria: - 18 years or older - Nonischemic dilated cardiomyopathy - Left ventricular ejection fraction 35% or less - Stable heart failure symptoms - Able to undergo both positron emission tomography and magnetic resonance imaging with gadolinium - Able to tolerate treatment with spironolactone Exclusion Criteria: - Serum potassium >5.0 - Serum creatinine >2.5 - Contraindications to magnetic resonance imaging such as internal cardioverter-defibrillator.


NCT ID:

NCT00574119


Primary Contact:

Principal Investigator
Marvin W Kronenberg, MD
Vanderbilt University School of Medicine


Backup Contact:

N/A


Location Contact:

Nashville, Tennessee 37232
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: August 21, 2017

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