We hypothesize that the stroke volume variation measured using the commercially available
LiDCO monitor provides a reasonable estimate of volume when compared to standard measures.
This study will collate data that is already being collected by the bedside nurses.
Objective: To compare measurement of stroke volume variance with intake/output measurements,
weight, BUN/Creatnine values, and central venous pressure.
Design: Non-experimental, non-randomized observational comparative study.
Setting: The sixteen bed Neurocritical Care Unit at Duke University Hospital.
Patients: 45 adult (over 18 years) subjects with intracranial pathology who require volume
resuscitation. Only patients with current LiDCO monitoring will be considered eligible for
inclusion in the study.
Interventions: This is an observational study. Subjects will receive standard-of-care
treatment without additional intervention.
Data Analysis: All data will be collected by the principal investigator / study coordinator.
Personal patient information will be removed (deidentified) from the permanent data
collection records to protect patient confidentiality. Data collected will be entered into a
Microsoft Excel electronic spreadsheet and will be saved on a USB Disk drive to be stored in
a locked cabinet in the investigator's office. Statistical analysis using SAS v9.1, (Cary,
NC) will be conducted with a level of significance set at .05 (alpha) using standardized
comparative analysis techniques.
- Admitted to the neurocritical care unit have an arterial line in place already
connected to LiDCO monitor Physician order for monitoring intake and output
- pregnant females