Expired Study
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Lakewood, California 90712


Purpose:

To evaluate if tiotropium (Spiriva)induced bronchodilation of inspiratory capacity in patients with moderate to severe copd subjected to metronome paced hyperventilation induced dynamic hyperinflation is dependent upon the extent of underlying emphysema as determined by high resolution-thin section CT lung.


Study summary:

We will analyze post hoc, data that was previously published: Gelb AF et al.Chest 2006;131:690-695. We have shown that tiotropium increases resting inspiratory capacity thereby providing lung volume protection against metronome paced hyperventilation induced dynamic hyperinflation. End point will be to correlate increase in tiotropium induced FEV 1(L) and inspiratory capacity with extent of underlying emphysema as scored by lung CT ( Gelb AF et al:Chest 1996; 109: 353-359)in 29 patients with COPD. We will also correlate the decrease in inspiratory capacity following metronome paced hyperventilation induced dynamic hyperinflation with extent of lung CT scored emphysema.


Criteria:

Inclusion Criteria - moderate to severe copd Exclusion Criteria - unable to tolerate tiotropium - unable to perform metronome paced hyperventilation induced dynamic hyperinflation


NCT ID:

NCT00570544


Primary Contact:

Principal Investigator
Arthur F Gelb, MD
Arthur F Gelb Medical Corporation


Backup Contact:

N/A


Location Contact:

Lakewood, California 90712
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 24, 2017

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