Expired Study
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Little Rock, Arkansas 72205


Purpose:

This 7 week, open-label pilot clinical trial will examine the safety and tolerability of modafinil up to 400mg/day as a potential treatment to reduce methamphetamine use in methamphetamine-dependent volunteers.


Criteria:

Inclusion Criteria: - 18-65 years old - not currently enrolled in a treatment program - subjects must have a history of methamphetamine use with recent use confirmed by a positive urine toxicology screen for amphetamines during the month prior to study entry - subjects must meet DSM-IV criteria for amphetamine dependence as assessed by the substance abuse section of the Structured Clinical Interview for DSM-IV (SCID) - women of childbearing age must have a negative pregnancy test to enroll in this study, agree to monthly pregnancy testing, and agree to use appropriate forms of birth control for the duration of the study Exclusion Criteria: - current diagnosis of alcohol, opiate, or sedative physical dependence - ill health (e.g., major cardiovascular, renal, endocrine, hepatic disorder) - history of schizophrenia, or bipolar type I disorder - present or recent use of over-the-counter or prescription psychoactive drug or drug(s) that would be expected to have major interaction with drug to be tested - medical contraindication to receiving study medications (e.g., allergy to modafinil, treatment with cyclosporine, clomipramine, or desipramine) - Current suicidality or psychosis - liver function tests (i.e., liver enzymes) greater than three times normal levels - pregnancy or breastfeeding


NCT ID:

NCT00569374


Primary Contact:

Principal Investigator
Dr. Janette McGaugh, MD
University of Arkansas


Backup Contact:

N/A


Location Contact:

Little Rock, Arkansas 72205
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 21, 2017

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