Expired Study
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Lakewood, California 90712


Purpose:

We will detect dynamic hyperinflation (DH) in 40 COPD (chronic obstructive pulmonary disease) patients with moderately severe disease using metronome paced hyperventilation (MPH) with inspiratory capacity as the primary end point. Hypothesis: Is tiotropium capable of lung volume protecting inspiratory capacity from MPH induced DH vs placebo in a randomized crossover double blinded study.


Study summary:

Study completed with 29 patients studied. Data is being analyzed to evaluate trough and peak effect of 18 µg tiotropium vs placebo on FEV 1 (L)(forced expiratory capacity in one second), inspiratory capacity and functional residual volume. In addition, we will study the effect of 18 µg tiotropium vs placebo on metronome paced hyperventilation induced dynamic hyperinflation. We will also evaluate the effect of tiotropium induced increase in IC (inspiratory capacity) vs extent of emphysema as evaluated on high resolution thin section CT lung


Criteria:

Inclusion Criteria: - Moderately severe COPD patients age 40-85 yr with post 180ug albuterol FEV 1 between 60 and 79% predicted and FEV 1/FVC < 70%. - Smoking history > 10 pack yr. - Clinically stable X 6 weeks. - No oxygen usage. Exclusion Criteria: - History of asthma - Clinically unstable - Any other significant medical problem precluding full cooperation for study


NCT ID:

NCT00569270


Primary Contact:

Principal Investigator
Arthur F Gelb, MD
Arthur F Gelb Medical Corporation


Backup Contact:

N/A


Location Contact:

Lakewood, California 90712
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 24, 2017

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