The goal of this study is to facilitate early diagnosis of gum disease. Proteins associated
with cell death will be isolated from gum pockets of diseased and healthy patients and
Early detection of the progression of periodontitis is difficult because it typically relies
on comparisons of clinical measurements made with a calibrated probe and nonstandardized
radiographs over time. Both methods detect periodontal breakdown only after it has occurred.
Therefore, considerable emphasis has been placed on identifying more specific and sensitive
methods to diagnose and detect periodontal disease progression. The overall goal of this
project is to determine whether specific apoptosis-associated proteins, specifically
fibronectin (FN) fragments, caspase-3, soluble Fas, and soluble Fas ligand, sampled from
gingival crevicular fluid (GCF) can be used as markers for periodontal disease progression.
- Adults over age of 18
- Healthy or diagnosis of periodontitis
- Active treatment with anti-inflammatory agents such as NSAIDs or steroids and