Stanford, California 94305


Purpose:

The purpose of this study is to identify and confirm new blood and tissue markers for prognosis and tumor hypoxia. Tumor hypoxia, or the condition of low oxygen in the tumor, has been shown to increase the risk of tumor spread and enhance tumor resistance to the standard treatment of radiation and chemotherapy in head and neck and lung cancers. We have recently identified several proteins or markers in the blood and in tumors (including osteopontin, lysyl oxidase, macrophage inhibiting factor and proteomic technology) in the laboratory that may be able to identify tumors with low oxygen levels or more aggressive behaving tumors.


Study summary:

The endpoints of the study are 1. To validate the prognostic significance of OPN in H&N and lung cancer patients and to monitor its level during active therapy and follow up for cancer surveillance. 2. To identify a gene and protein signature for hypoxia in H&N and lung cancer patients.


Criteria:

Inclusion Criteria:Newly diagnosed patients with head and neck cancer who has tumor accessible to tumor oxygenation measurement with a microelectrode.


NCT ID:

NCT00568490


Primary Contact:

Principal Investigator
Quynh-Thu Le
Stanford University


Backup Contact:

N/A


Location Contact:

Stanford, California 94305
United States

Amanda Simmons
Phone: 650-724-4606
Email: amandals@stanford.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: September 22, 2017

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