Expired Study
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Lakewood, California 90712


To evaluate the role of inhaled corticosteroids to suppress nitric oxide gas exchange in stable patients with moderate-to-severe COPD who are current non-smokers and not on oral corticosteroids.

Study summary:

Stable, non-smoking COPD patients not on oral corticosteroids will be randomized in single blinded study to evaluate nitric oxide gas exchange at baseline, and subsequent effects of fluticasone 100mcg/salmeterol 50mcg bid, and fluticasone 250mcg/salmeterol 50mcg bid. Primary end points will include measurements of nitric oxide at varying expiratory flow rates to calculate bronchial, and small airway/alveolar nitric oxide. Secondary end points will evaluate lung function. Exhaled nitric oxide production presumably reflects endogenous inflammation. Normal healthy, non-smoking controls will be used for comparison, with exhaled nitric oxide measured before and after 3 weeks of low dose inhlaed corticosteroids.


Inclusion Criteria: - Clinical diagnosis of copd - Current non-smoker - Not on oral corticosteroids - Must be able to use Advair discus or salmeterol discus Exclusion Criteria: - Pregnancy - Current smoker - On corticosteroids - Clinically unstable



Primary Contact:

Principal Investigator
Arthur F Gelb, MD
Arthur F Gelb Medical Corporation

Backup Contact:


Location Contact:

Lakewood, California 90712
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

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