Expired Study
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Boston, Massachusetts 02114


Purpose:

The purpose of the study is to see if galantamine HBr (Razadyne) is safe and can help treat problems with thinking and memory caused by electroconvulsive therapy (ECT).


Criteria:

Inclusion Criteria: - Criteria to enter the study include males and females between the ages of 18-90 (females must be post menopausal) and a DSM-IV diagnosis of Major Depressive Disorder, Major Depressive Disorder with psychotic features, Bipolar Disorder, depressed type, or Schizoaffective Disorder, depressed type (19). Exclusion Criteria: - DSM-IV diagnoses of dementia and its subtypes - Substance use disorder (active use within the last 6 months) - Organic mental disorders; seizure disorder - Unstable physical disorder or physical disorder judged to significantly affect the central nervous system function - A heart rate of <60 - A systolic blood pressure < 90 - Heart block - Pre-existing sick-sinus - Chronic treatment with beta blockers - Any cardiac arrythmia - Hypotension - Coronary artery disease - Liver and renal function impairment - Urge incontinence, colitis Crohn's disease, GI motility disorders, asthma and COPD - Treatment with anti-cholinergic and cholinomimetic medications; and - Female patients who are pregnant. - Additionally, women subjects must be postmenopausal, surgically sterile, or using prescription oral contraceptives (e.g. estrogen-progestin combinations) , contraceptive implants (e.g. NorplantTM, DepoProveraTM ), or transdermally delivered contraceptives (Ortho EvraTM) before entry and throughout the study; and have a negative serum b-HCG pregnancy test at screening. Note: Abstinence and the use of double barrier contraceptive methods are not acceptable in this study.


NCT ID:

NCT00566735


Primary Contact:

Principal Investigator
John D Matthews, MD
Massachusetts General Hospital


Backup Contact:

N/A


Location Contact:

Boston, Massachusetts 02114
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: August 17, 2017

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