The proposed prospective study aims to determine whether interpretation of PSA levels in
morbidly obese men require correction due to the obesity itself. If PSA levels are found
to rise after weight loss, interpretation of PSA levels in morbidly obese men may be
improved by upward correction of the PSA level. A 'correction factor' may be proposed for
the interpretation of PSA levels in obese men, toward the clinical decision regarding
indication for prostate biopsy.
The main objective of this study is to determine whether interpretation of PSA levels in
morbidly obese men require correction due to the obesity itself. Secondary outcome measures
that will be followed include the affect of obesity and weight loss on testosterone,
estradiol and leptin. In as much as these might also affect PSA, we will be measuring these
values as well. Also, we do not know the effects of lap-band induced weight loss on
clinical outcome measures of sexual, bowel and urinary function. Thus we will aim to
investigate these parameters as well.
- obese men undergoing lap-band surgey
- prior diagnosis of prostate cancer, prior prostate surgery, use of 5-alpha reductase
inhibitors and history prostatitsis or recurrent UTI.