Expired Study
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Atlanta, Georgia 30322


Purpose:

Hypothesis:Anti-[18F]FACBC PET-CT will adequately detect local and extraprostatic recurrence, and lead to better characterization of disease status in restaging patients. This is a study that will test a compound (chemical substance) that has a small amount of radioactivity attached to it. This substance has a natural tendency to go to prostate tissue. The substance is called [18]FACBC and it is given in the form of an injection into a vein. After the substance reaches the prostate, scans called PET or Positron Emission Tomography, are done. This is similar to having CAT scans or x-rays. Usually a compound called [18]FDG is used for PET scans but this substance is eliminated by the kidneys and cannot reach the prostate. This substance called [18]FACBC is not eliminated by the kidneys and may allow tumors in the prostate to be seen better. It is sometimes difficult to tell if a growth on the prostate is cancer with scans or x-rays that are usually done. This study will look at how the [18]FACBC goes into the prostate tissue and determine its ability to detect recurrent prostate cancer.


Criteria:

STUDY NOW CLOSED for recruitment Inclusion Criteria: - Patients must be 18 years of age or older. - Patients will have been originally diagnosed with localized (Stage T1c, T2, or T3 ) prostate carcinoma and have undergone what was considered definitive therapy for localized disease. - In the case of brachytherapy, cryotherapy, or external beam radiation, treatment will have occurred at least 2 years in the past to eliminate patients with so-called "PSA bump." - Patient will have suspicion of recurrent prostate carcinoma as defined by: ASTRO criteria of three consecutive rises of PSA or earlier if clinically appropriate, and/or nadir + 2.0 after radiotherapy, and/or greater than 0.3 after prostatectomy. - Ability to lie still for PET scanning - Patients must be able to provide written informed consent. Exclusion Criteria: - Age less than 18. - Greater than T3 disease in past - Prior prostatectomy or 2 years since brachytherapy, cryotherapy, or external beam radiation therapy. - Does not meet above criteria of suspicious PSA elevation - Inability to lie still for PET scanning - Cannot provide written informed consent. - Bone scan findings characteristic for metastatic prostate carcinoma - Less than 2 months since any prior prostate biopsy (to decrease false positive uptake from inflammation).


NCT ID:

NCT00562315


Primary Contact:

Principal Investigator
David M Schuster, MD
Emory University


Backup Contact:

N/A


Location Contact:

Atlanta, Georgia 30322
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 24, 2017

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