Expired Study
This study is not currently recruiting Study Participants on ClinicalConnection.com. If you would like to find active studies please search for clinical trials.

Durham, North Carolina 27705


Purpose:

This study will test the therapeutic potential of augmenting a stable SSRI regimen with the neurosteroid pregnenolone to reduce cognitive symptoms and PTSD symptoms in patients diagnosed with PTSD.


Study summary:

See brief summary


Criteria:

Inclusion Criteria: 1. 18-65 years of age, any ethnic group, either sex 2. DSM-IV diagnosis of PTSD by MINI (see schedule of events) 3. No change in SSRI medications for > 4 weeks. 4. No anticipated need to alter any psychotropic medications for the 10-week duration of the study. 5. Ability to fully participate in the informed consent process, or have a legal guardian able to participate in the informed consent process. Exclusion Criteria: 1. Unstable medical or neurological illness, including seizures, CVA, prostate or breast cancer 2. Use of oral contraceptives or other hormonal supplementation such as estrogen. 3. Significant suicidal or homicidal ideation. 4. Concomitant medications for medical conditions will be addressed on a case-by-case base to determine if exclusionary. 5. Current DSM-IV diagnosis of bipolar disorder, schizophrenia or other psychotic disorder, or cognitive disorder due to a general medical condition; history of substance dependence within the last 3 months 6. Female patients who are pregnant or breast-feeding. 7. Known allergy to study medication. 8. Drugs with a narrow therapeutic index (e.g. thioridazine, mesoridazine, ziprasidone, clozapine, etc.) will be excluded, as suggested by the FDA; patients taking these agents will not be eligible for this study.


NCT ID:

NCT00560781


Primary Contact:

Principal Investigator
Christine E Marx, MD MA
Durham VAMC


Backup Contact:

N/A


Location Contact:

Durham, North Carolina 27705
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: August 22, 2017

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

This study is not currently recruiting Study Participants on ClinicalConnection.com. The form below is not enabled.