The purpose of this study is to determine the effectiveness and safety of Topical
Bevacizumab (Avastin) for treatment of corneal neovascularization.
Primary outcomes measures included neovascular area (NA), defined as the area of the corneal
vessels themselves; vessel caliber (VC), defined as the mean diameter of the corneal
vessels; and invasion area (IA), defined as the fraction of the total cornea into which the
vessels extend. The occurrence of ocular and systemic adverse events was closely monitored
throughout the course of the study.
- Male or female, at least 18 years of age
- Clinical stable corneal neovascularization (as defined above)
- Ability to understand and provide informed consent to participate in this study and
willingness to follow study instructions and likely to complete all required visits.
- All female patients of childbearing potential will be excluded. A female is
considered to be of childbearing potential unless she is postmenopausal and without
menses for 12 months or without a uterus and/or both ovaries.
- Current or recent (≤ 1 month) systemic corticosteroid therapy or periocular
corticosteroid injections to the study eye
- Current or recent (≤ 3 months) intravitreal drug injection to the study eye; recent
(≤ 1 month) change in dose and frequency of topical steroids and/or non-steroidal
- Uncontrolled hypertension defined as systolic blood pressure of ≥ 150 mmHg or
diastolic blood pressure of ≥ 90 mmHg; history of a thromboembolic event, including
myocardial infarction or cerebral vascular accident
- Patients age 75 or older; history of renal abnormalities
- Recent (≤ 3 months ) or planned surgery
- History of coagulation abnormalities, including end stage liver disease or current
anticoagulation medication other than aspirin (warfarin, heparin, enoxaparin, or
similar anticoagulant agent)
- All female patients of childbearing potential (a female is considered to be of
childbearing potential unless she is postmenopausal and without menses for 12 months
or without a uterus and/or both ovaries)
- Any condition (including language barrier) that precludes patient's ability to comply
with study requirements including completion of study