Expired Study
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Boston, Massachusetts 02114


Purpose:

The purpose of this study is to determine the effectiveness and safety of Topical Bevacizumab (Avastin) for treatment of corneal neovascularization.


Study summary:

Primary outcomes measures included neovascular area (NA), defined as the area of the corneal vessels themselves; vessel caliber (VC), defined as the mean diameter of the corneal vessels; and invasion area (IA), defined as the fraction of the total cornea into which the vessels extend. The occurrence of ocular and systemic adverse events was closely monitored throughout the course of the study.


Criteria:

Inclusion Criteria: - Male or female, at least 18 years of age - Clinical stable corneal neovascularization (as defined above) - Ability to understand and provide informed consent to participate in this study and willingness to follow study instructions and likely to complete all required visits. - All female patients of childbearing potential will be excluded. A female is considered to be of childbearing potential unless she is postmenopausal and without menses for 12 months or without a uterus and/or both ovaries. Exclusion Criteria: - Current or recent (≤ 1 month) systemic corticosteroid therapy or periocular corticosteroid injections to the study eye - Current or recent (≤ 3 months) intravitreal drug injection to the study eye; recent (≤ 1 month) change in dose and frequency of topical steroids and/or non-steroidal anti-inflammatory agents - Uncontrolled hypertension defined as systolic blood pressure of ≥ 150 mmHg or diastolic blood pressure of ≥ 90 mmHg; history of a thromboembolic event, including myocardial infarction or cerebral vascular accident - Patients age 75 or older; history of renal abnormalities - Recent (≤ 3 months ) or planned surgery - History of coagulation abnormalities, including end stage liver disease or current anticoagulation medication other than aspirin (warfarin, heparin, enoxaparin, or similar anticoagulant agent) - All female patients of childbearing potential (a female is considered to be of childbearing potential unless she is postmenopausal and without menses for 12 months or without a uterus and/or both ovaries) - Any condition (including language barrier) that precludes patient's ability to comply with study requirements including completion of study


NCT ID:

NCT00559936


Primary Contact:

Principal Investigator
Reza Dana, M.D., MPH
Massachusetts Eye and Ear Infirmary


Backup Contact:

N/A


Location Contact:

Boston, Massachusetts 02114
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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