Expired Study
This study is not currently recruiting Study Participants on ClinicalConnection.com. If you would like to find active studies please search for clinical trials.

Dallas, Texas 75390


Purpose:

The purpose of this study is to determine if an 8hr infusion of nesiritide in the emergency department in the Acutely decompensated heart failure patients will decrease 30 day recidivism.


Study summary:

In view of the high return admission rate to our county ED for heart failure, we hypothesized that our higher risk patient population might realize a decrease in the return admission rate as a benefit from early ED administration of nesiritide. We also acknowledged that the safety of nesiritide in our patient population had not been well established. Thus, we opted to test the hypothesis that an 8-hour ED infusion of nesiritide [in addition to protocol specified standard therapy] in ADHF patients from an urban patient population consisting of predominately African Americans and Hispanics will decrease 30-day readmission rates without provoking harm.


Criteria:

Inclusion Criteria: - Patients who were adults greater than 18 years of age - A history of established heart failure - Dyspnea at rest or with minimal exertion and with a respiratory rate greater than 24 breaths per minute - Evidence of volume overload based on physical exam findings or chest radiograph, and a brain natriuretic peptide (BNP) level greater than 100 pg/ml. Exclusion Criteria: - Systolic blood pressure of less than 90 mm Hg - Frank or impending cardiogenic shock - Cardiopulmonary arrest - Evidence of low cardiac output (cold clammy extremities - Mental status changes) - New onset congestive heart failure - Suspected acute coronary syndrome (elevated troponin, New electrocardiographic changes, or history consistent with cardiac ischemia) - High clinical suspicion of pulmonary embolism - End-stage renal disease (on dialysis or imminent) - Active use of nitroglycerin or inotropic infusions in the ED - Ventricular tachycardia - Allergy to nesiritide or its components - Patient not needing intravenously diuretic therapy in the ED - Normal BNP level - Inability to follow-up - Pregnancy or suspected pregnancy; or - Actively receiving other investigational drug.


NCT ID:

NCT00559338


Primary Contact:

Principal Investigator
Adam H Miller
UT Southwestern Medical Center Dallas


Backup Contact:

N/A


Location Contact:

Dallas, Texas 75390
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: August 22, 2017

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

This study is not currently recruiting Study Participants on ClinicalConnection.com. The form below is not enabled.