This study will evaluate and follow patients with various allergic, hypersensitivity and
inflammatory disorders. The protocol is not designed to test new treatments; patients will be
managed with standard of care therapies. Participants may be referred to other current NIAID
protocols as appropriate or to new studies as they are developed, but will not be required to
join another study.
Patients with allergic, hypersensitivity or inflammatory disorders between the ages of 3
years and 80 years may be eligible for this study. Conditions of interest include, but are
not limited to, asthma, allergic rhinitis, mastocytosis, atopic dermatitis and food allergy.
Participants will have a medical history and physical examination, plus standard tests for
diagnosing and treating their specific disorder. Tests may include routine blood and urine
studies, X-rays or other imaging studies, allergy skin tests and lung function tests. Blood
samples may be collected for research on immune system cells and other substances involved in
immune function. Generally, about 2 to 6 tablespoons will be drawn at a time, but no more
than 16 ounces will be collected over a 6-week period.
NIH does not provide emergency medical treatment or treatment for other, unrelated conditions
the patient may have. Therefore, patients must maintain a personal physician for these
Allergic, hypersensitivity and inflammatory disorders, including but not limited to asthma,
allergic rhinitis, mastocytosis, atopic dermatitis and food allergy are exceedingly common
disorders. The pathogenesis of these various disorders are being investigated under a number
of Laboratory of Allergic Diseases clinical research protocols. This protocol is an
evaluation and long term follow-up protocol of such disorders, for the purposes of
maintaining a group of patients on which LAD investigators draw for our other various
protocols. The patients admitted under this protocol also provide training and experience for
members of the NIAID Allergy and Immunology fellowship training programs.
- INCLUSION CRITERIA:
Males and females ages 3 years to 80 years.
Allergic, hypersensitivity or inflammatory diseases.
Willingness to participate in clinical protocols when appropriate.
Subjects must maintain a private physician for non-protocol related medical complaints and
for emergency medical treatment required for these or other of their disorders.
Unacceptably poor compliance which, in the opinion of the investigator, would interfere
with one's ability to study or provide quality medical care for the patient.