RATIONALE: Gathering information about patients with a personal or family history of cancer
associated with a virus may help doctors learn more about the disease.
PURPOSE: This clinical trial is studying patients with a personal or family history of
cancer caused by a virus.
- Conduct clinical, laboratory, and epidemiologic studies of patients with a personal or
family history of viral-associated cancer.
OUTLINE: Patients undergo an interview, physical examination, and blood sample collection.
Other clinically indicated biological samples, such as urine, sputum, saliva, tears, or
semen or cervical, anal, oral, or nasal swabs, are collected. Skin testing with
conventional, licensed antigens for assessment of cellular immunity may be performed, and
skin lesions may be biopsied or excised. Tumor or other tissue biopsies may be obtained when
biopsy or surgery is clinically indicated. The biological samples are frozen or preserved
for current or future research studies.
Patients receive counseling relevant to the disease under study, and about the interim study
results. Clinical referrals are made as needed.
- Personal or family history of viral-associated neoplasia of an unusual type, pattern,
or number including, but not limited to, the following:
- Kaposi sarcoma
- Known or suspected factor(s) predisposing to neoplasia, including any of the
- Environmental exposure (particularly immunological or virological exposure)
- Genetic or congenital factors (e.g., Mendelian traits predisposing to neoplasia,
birth defects, or chromosomal anomalies)
- Unusual demographic features
- Referred to the National Cancer Institute (NCI) Viral Epidemiology Branch
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified