Expired Study
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Boston, Massachusetts 02119


Purpose:

Physical inactivity induces vascular dysfunction and glucose intolerance during five days of bed rest. This study will investigate the effects of salsalate on these responses. Subjects will be randomized to treatment with salsalate or placebo for four days prior to initiation of bed rest. Vascular function in the brachial artery will be determined by ultrasound prior to treatment and before and after the 5-day bed rest protocol. We hypothesize that treatment with salsalate will be associated with protection again the development of glucose intolerance and vascular dysfunction in this setting.


Criteria:

Inclusion Criteria: - Healthy volunteers Exclusion Criteria: - Pregnancy - History of Coronary Artery Disease - Diabetes Mellitus - Hypertension - Cigarette smoking - History or family history of deep vein thrombosis or pulmonary embolism - Abnormal renal function - Liver function tests greater than two times the upper limit of normal - Anemia - Use of viagra or other PDE5 inhibitor - Hypercholesterolemia - Aspirin allergy/sensitivity - Asthma with nasal polyps - Peptic ulcer disease/Gastrointestinal bleeding - Any ongoing drug treatment


NCT ID:

NCT00553995


Primary Contact:

Principal Investigator
Naomi Hamburg, MD
Boston Medical Center


Backup Contact:

N/A


Location Contact:

Boston, Massachusetts 02119
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: August 22, 2017

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