Expired Study
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Boston, Massachusetts 02114


The purpose of this study is to determine whether Restasis is an effective treatment for preventing the occurrence and progression of dry eye syndrome in patients who have recently received a bone marrow transplant and are at risk to graft-versus-host disease.


Inclusion Criteria: - Male or female - At least 18 years of age - Approved candidate for allogeneic HSCT - Ability to understand and provide informed consent to participate in this study - Willingness to follow study instructions and likely to complete all required visits Exclusion Criteria: - History of ocular or eyelid surgery - History of glaucoma or ocular hypertension - History of herpetic eye disease - Patient with acne rosacea, blepharitis, or meibomitis, in the opinion of the investigator - Any ocular disorder or condition (including ocular infection, trauma, and disease) that could possibly interfere with the interpretation of the study results - Recent (3-month) history of wearing contact lens - Anticipated contact lens wear during any portion of the study - Recent (3-month) history of current use of topical steroids or antiglaucoma agents - Any punctal occlusion within 2 months of the screening visit - Significant sign or symptoms of dry eye (the definition of "dry eye" used for exclusion criteria is compatible with the recommendations of the NEI/Industry Workshop on Clinical Trials in Dry Eyes (Lemp, 1995) (see Appendix 1and 2)) - History of connective tissue disease or diabetes - Any condition (including language barrier) that precludes patient's ability to comply with study requirements including completion of study



Primary Contact:

Principal Investigator
Reza Dana, M.D.
Massachusetts Eye and Ear Infirmary

Backup Contact:


Location Contact:

Boston, Massachusetts 02114
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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