Multidisciplinary antimicrobial utilization teams (AUT) have been proposed as an effective
mechanism for improving antimicrobial use, but data on their efficacy remain limited. The
researchers postulated that a multi-disciplinary AUT would improve antimicrobial use in a
teaching hospital when compared to the standard of care (no AUT intervention).
Design: Randomized-controlled intervention trial. Setting: A 953-bed urban teaching
Patients: Patients admitted to internal medicine ward teams who were prescribed selected
antimicrobial agents (piperacillin-tazobactam, levofloxacin, or vancomycin) during the
10month study period.
Intervention: Eight internal medicine ward teams were randomized monthly to academic
detailing by the AUT while 8 internal medicine ward teams were randomized indication-based
prescription of broad spectrum antimicrobials.
Measurements: Proportion of appropriate empiric, definitive, and end antimicrobial usage
(antimicrobial use from the initiation of therapy until definitive therapy is prescribed).
This study was conducted when Bernard C Camins, MD (BCC), one of the investigators, was
still employed at Emory University. The principal investigator is no longer at Emory
University. This trial is being registered by one of the investigators, BCC, so we can
submit the manuscript for publication. BCC is now at Washington University and this study
was conducted while he was at Emory University.
- All patients prescribed vancomycin, piperacillin-tazobactam, or levofloxacin during
the time period of the study.