Primary graft dysfunction (PGD) is a severe lung complication that can occur in the days
after lung transplant surgery. This study will analyze blood samples to determine if high
levels of certain chemicals may increase the risk of developing PGD after a lung transplant.
PGD is a severe complication that affects up to 25% of lung transplant patients following
surgery. Pulmonary edema, which is an abnormal build-up of fluid in the lungs, and hypoxemia,
which is low blood oxygen levels, are two common symptoms that individuals with PGD
experience. Treatment for PGD is often expensive, and it is the leading cause of death
following lung transplantation. Many potential lung donors and recipients are considered
unsuitable for lung transplantation because of concern for the development of PGD. Increased
levels of chemicals that are involved in bleeding and clotting, including protein C, and
certain markers of oxidant stress, which can cause damage to the body's cells and tissues,
may increase a person's risk of developing complications following a lung transplant. The
purpose of this study is to analyze blood samples to determine if elevated levels of certain
chemicals may be associated with an increased risk of developing PGD after lung
This study will enroll individuals who are undergoing lung or heart and lung transplantation.
Blood samples will be collected from participants prior to surgery, immediately following
surgery, and 24 hours after surgery. Study researchers will also review participants' medical
records. There will be no additional study visits.
- Undergoing lung or combined heart and lung transplantation
- Undergoing combined organ transplantation other than heart and lung transplantation
Jason D. Christie, MD
University of Pennsylvania
E.J. Demissie, MSN