The purpose of this study is to determine if use of Nortriptyline will improve symptoms and
quality of life in patients who have nonulcer dyspepsia.
Nonulcer dyspepsia is a common complaint in clinical practice and its management should be
based on the best evidence. Many clinical trials of nonulcer dyspepsia suffer from
important weaknesses in trial design. This makes it difficult to determine whether truly
efficacious therapies exist for this disorder.
Once a diagnosis of nonulcer dyspepsia is confirmed by normal endoscopy, a trial of therapy
is commonly prescribed. However, the benefits of all therapies in this condition have been
questioned. Small studies have suggested benefit in use of antidepressants such as
Nortriptyline and even though the data is insufficient, antidepressants such as
Nortriptyline are widely used in clinical practice largely due to lack of proven, reliable
therapies for nonulcer dyspepsia.
Our hypothesis is that Nortriptyline will improve symptoms of nonulcer dyspepsia and improve
quality of life.
- Men and Women
- Ages 18-65
- Meet Rome III criteria for functional dyspepsia
- Endoscopy within 1 year
- Allergic reaction or history of adverse events with Nortriptyline or tricyclic
- Organic cause found on physical examination
- Organic cause found on lab work: CBC, CMP, TSH, Tissue transglutaminase IgA
- Predominantly GERD symptoms
- Current Helicobacter pylori infection
- History of PUD
- NSAID use > 2x/wk
- Pregnant or planning pregnancy
- History of major depression
- Abdominal surgery in the last year