Expired Study
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Bethesda, Maryland 20892


Purpose:

This study will collect representative blood samples from healthy children and adults and from children and adults who have unique red blood cell features that are related to sickle cell disease. Sickle cell disease is a blood disease that limits the ability of red blood cells to carry oxygen throughout the body. The purpose of the study is to collect a variety of blood samples that may then be used to investigate advances and potential new drug treatments for sickle cell disease. Volunteers must be at least 8 years of old. Samples will be taken both from healthy volunteers and from volunteers who have unique red blood cell features that are related to sickle cell disease. Candidates will be screened with a medical history. During the study, participants will undergo a one- to two-hour outpatient procedure at the National Institutes of Health Clinical Center. Once researchers have explained the study and obtained the participant s consent, participants will donate 8 cc (approximately 2 teaspoons) of blood. Because repeat testing helps researchers validate study findings, participants who have the unique red blood cell features mentioned above may also be asked if they are willing to return and donate another 2 cc to 8 cc of blood for additional studies. The amount of blood drawn will not exceed 50 ml with any eight-week period for adults or 7 cc within any six-week period for children.


Study summary:

The critical event leading to serious morbidity in sickle cell disease is polymerization of the abnormal hemoglobin to form fibers that stiffen and distort red blood cells and consequently, cause vaso-occlusion in the small vessels of the tissues. Currently, hydroxyurea is the only approved drug for treating sickle cell disease, but is only partially effective. This protocol seeks to identify by high sensitivity in vitro screening methods additional compounds that inhibit sickling. Subjects with sickle cell trait or disease and normal volunteers will be asked to donate blood samples for studies to verify their hemoglobinopathies and then periodically donate small volume samples of fresh blood for use in ongoing high throughput screening tests to identify potentially clinically useful anti-sickling drugs.


Criteria:

- INCLUSION CRITERIA: - Patients with sickle cell trait - Patients with known hemoglobinopathies involving one or two genes for sickle hemoglobin - Healthy volunteers for control experiments - Women who are pregnant or breastfeeding are eligible to enroll in this protocol. - A pregnant or breastfeeding woman will not be enrolled of the donation of research bloos samples poses any clinical risk. - No pregnant minors will be enrolled. - Age range: Minors greater than or equal to 8 years of age and adults greater than or equal to 18 years of age EXCLUSION CRITERIA: - Subjects who are unable to comprehend the investigational nature of the laboratory research are ineligible to enroll in this protocol. - As a safety precaution in handling the blood samples, patients with HIV, Hepatitis B or Hepatitis C will be excluded from the study. HIV, Hepatitis B or Hepatitits C testing will not be done under this study. Participants must be co-enrolled under another NIH protocol where the screening evalustion has been performed.


NCT ID:

NCT00542230


Primary Contact:

Principal Investigator
William A Eaton, M.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)


Backup Contact:

N/A


Location Contact:

Bethesda, Maryland 20892
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: August 22, 2017

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