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Pittsburgh, Pennsylvania 15213


Purpose:

The objective of this study is to develop a new aerosol-based technique for quantifying liquid absorption in the airways of subjects with cystic fibrosis(CF) that can be used to help develop new therapies. In CF, mutations in the CF gene result in dysfunction of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) ion channel on the cells that line the airway epithelium, causing improper fluxes of ions such as sodium, chloride, and bicarbonate. The so called "low volume" hypothesis of CF pathogenesis contends that abnormal absorption of ions from the airways causes excessive absorption of liquid, resulting in an airway surface liquid layer that is dehydrated and difficult to clear. Here we are trying to develop a means of measuring liquid absorption from the airways so that therapies that would propose to correct this basic defect of CF lung disease can be effectively tested.


Criteria:

Inclusion Criteria: - Cystic fibrosis subjects and healthy controls - Age ≥ 18 years - Diagnosis of cystic fibrosis as determined by sweat test or genotype and clinical symptoms (CF subjects) - Clinically stable as determined by the investigator (pulmonologist) Exclusion Criteria: - Reactive airways disease - Tobacco smokers (regular smoking within 6 months of enrollment) - Positive urine pregnancy test on the day of testing - FEV1p value of < 50% - SaO2 < 92%, or if they require supplemental oxygen. - Subjects performing other radioisotope studies within the last 2 weeks will be excluded. - Healthy subjects with any history of lung disease will be excluded. - Women currently breastfeeding - Subjects not willing to stop treatments with inhaled hypertonic saline for 48 hours in advance of the study.


NCT ID:

NCT00541190


Primary Contact:

Principal Investigator
Timothy E Corcoran, Ph.D.
University of Pittsburgh


Backup Contact:

N/A


Location Contact:

Pittsburgh, Pennsylvania 15213
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 19, 2017

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