Expired Study
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New Brunswick, New Jersey 08903


Purpose:

The purpose of this study is to devise a safe and effective method for transitioning patients from cyclosporine to alefacept.


Study summary:

The purpose of this study is to devise a safe and effective method for transitioning patients from cyclosporine to alefacept. Patients in the study are well controlled on cyclosporine and desire to switch to alefacept. The study is done in three phases. In Phase 1 (12 week duration) the two drugs will be overlapped, with cyclosporine slowly tapering. Both drugs will be discontinued after 12 weeks. In Phase 2 (12 weeks duration), patients are off both drugs. In Phase 3 (24 weeks long), patients are on a second course of alefacept alone for 12 weeks and then off for 12 weeks. Topical and UV light treatments are allowed throughout the study. Total length of study is one year.


Criteria:

Inclusion Criteria - Adult psoriasis patients (18 to 80 years old), who are well controlled on cyclosporine (Static PGA score of mild, minimal or clear) and who need or desire to stop cyclosporine and start alefacept. Exclusion Criteria - CD4 <400 - Active infection (other than trivial URI, etc.) - History of AIDS or Hepatitis B, C - Inability to understand consent or comply with study requirements - Pregnancy or Lactation - History of heart or liver disease


NCT ID:

NCT00143806


Primary Contact:

Principal Investigator
Alice Gottlieb, MD, PhD
University of Medicine and Dentistry New Jersey


Backup Contact:

N/A


Location Contact:

New Brunswick, New Jersey 08903
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: December 15, 2017

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