The study is to evaluate the effect of bifeprunox on the pharmacokinetics of valproate in
subjects with Bipolar I Disorder after multiple dose administration.
- Males or females
- 18-65 years old
- meeting DSM-IV criteria for Bipolar I Disorder, either manic or mixed episodes, with
or without psychotic features
- subjects who are acutely manic, acutely depressed, psychotic or subjects with a
current Axis I primary psychiatric diagnosis other than Bipolar I Disorder based on
DSM-IV TR criteria.