Expired Study
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Boston, Massachusetts


Purpose:

This study will compare the physiological effects of two isoenergetic, nutrient-controlled diets that differ in glycemic index. The diets will be studied in obese adults in a 10-day crossover feeding trial.


Study summary:

This study will compare the physiological effects of two isoenergetic, nutrient-controlled diets that differ in glycemic index. The diets will be studied in obese male adults in a 10-day crossover feeding trial. Hypothesis: Obese subjects will show improvements in clinical endpoints associated with risk for diabetes and cardiovascular disease (CVD) after consuming a controlled low (compared to high) glycemic index diet for 10 days. 1º endpoint: insulin sensitivity as measured by the modified Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT). 2º endpoints: CVD risk factors; postprandial studies of oxidative stress; thermic effect of food.


Criteria:

Inclusion Criteria: - age 18 to 35 years - male - BMI ≥ 27 ≤45 kg/m2 - willingness to refrain from alcohol and caffeinated beverage consumption for duration of study Exclusion Criteria: - major medical illness - an abnormal screening laboratory test - taking any prescription medications that might affect body weight - current smoking (1 cigarette during any of the last 7 days) - consuming special diets


NCT ID:

NCT00141076


Primary Contact:

Principal Investigator
David S Ludwig, MD, PhD
Children's Hospital Boston


Backup Contact:

N/A


Location Contact:

Boston, Massachusetts
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

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