Fort Sam Houston,
The purpose of this study is to compare one type of dressing against the current standard
dressing that is used to cover an unburned area of the skin where a piece of skin is removed
to cover another part of the body that was burned.
Hypothesis: The mean healing time for wounds treated with the Silverlon Dressing will be
less than the mean healing time for wounds treated with Xeroform Dressing.
At the time of the procedure, donor sites that are symmetrical in size and shape will be
selected. Once the grafts have been harvested, the wounds will be randomized for treatment
using either the Silverlon dressing or Xeroform. The wound dressings will then be observed
at least once a day beginning 72 hours after surgery until healed, defined as 90% or more of
the wound surface being confluently re-epithelized.
- 18 years or older; male or female.
- Burn wounds of less than 30% total body surface area (TBSA) with no systemic
- Burns do not involve the harvesting area
- Burn wounds require excision and grating of sufficient extent to justify two donor
sites of equal and symmetrical size on non-dependent body surface areas
- Scheduled excision and grafting procedures is the first such operation for subject
during this hospitalization
- Subject agrees to participate in follow-up evaluations
- Critical illnesses requiring ventilator support, systemic infection or hemodynamic
- Major acute or chronic illnesses affecting wound healing (e.g. peripheral vascular
disease, insulin dependent diabetes, blood clotting disorder)
- Subject receiving medications that inhibit/compromise wound healing (e.g.
anticoagulants, antiplatelet drugs, oral steroids). The use of anticoagulants does
not include deep vein thrombosis (DVT) prophylaxis.
- Cellulitis or other infection of potential donor site
- Previously harvested donor site
- Subject with greater than 30% TBSA burns
- Subjects with sensitivity to silver or nylon