The purpose of the study is to assess the effects of sustained aromatase inhibitor therapy
to reduce estrogen levels in elderly men with mild hypogonadism (a decreased level of sex
It has long been accepted that aging in men is associated with a slow, steady decline in
gonadal androgen (male sex hormone) production. Several studies have explored androgen
replacement, but the safety and efficacy of testosterone administration remains
controversial. Aromatase inhibitors may provide a particularly useful way to restore normal
androgen production in aging men.
This study will recruit 150 male volunteers, 60 years of age or older, to be randomized to
receive either anastrozole or a placebo for 24 months. Six visits are planned over the
96-week treatment period.
- Men ages 60 and older
- Serum testosterone between 150-300 ng/dL
- Symptoms suggestive of androgen deficiency