The purpose of this study is to investigate whether topically applied constituents of green
tea [caffeine or (-)-epigallocatechin gallate; EGCG] have a protective effect on skin exposed
to ultraviolet light (UV).
The purpose of this study is to investigate if topically applied constituents of green tea
[caffeine or (-) - epigallocatechin gallate; EGCG] have a protective effect on skin exposed
to ultraviolet light (UV). In the double-blinded study all subjects will receive 311
nanometer UVB light at a dose that is 0.5-1.5X their individual minimal erythema dose (MED).
One part of the experiment will involve applying a topical natural product (caffeine or EGCG)
and placebo to bilateral symmetric sites. The natural product and the placebo will be applied
immediately after and at 1/2 hour, 1 hour, 2 hours, 4 hours, 6 hours, 8 hours, 24 hours, 25
hours, and 27 hours after exposure to a 0.5-1.5 MED dose of UV light. Another part of the
study involves performing skin biopsies. One will be done prior to UVB exposure, 2 will be
done at 24 hours and 2 more will be done at 48 hours.
- The subjects will be normal adult volunteers who are 18 to 65 years of age.
- Subjects who drink more than two cups of coffee, tea, or caffeinated soda/beverages
- Subjects who are unable to get an erythemic response (i.e., a sunburn).