Expired Study
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New Brunswick, New Jersey 08901


Purpose:

The purpose of this study is to investigate whether topically applied constituents of green tea [caffeine or (-)-epigallocatechin gallate; EGCG] have a protective effect on skin exposed to ultraviolet light (UV).


Study summary:

The purpose of this study is to investigate if topically applied constituents of green tea [caffeine or (-) - epigallocatechin gallate; EGCG] have a protective effect on skin exposed to ultraviolet light (UV). In the double-blinded study all subjects will receive 311 nanometer UVB light at a dose that is 0.5-1.5X their individual minimal erythema dose (MED). One part of the experiment will involve applying a topical natural product (caffeine or EGCG) and placebo to bilateral symmetric sites. The natural product and the placebo will be applied immediately after and at 1/2 hour, 1 hour, 2 hours, 4 hours, 6 hours, 8 hours, 24 hours, 25 hours, and 27 hours after exposure to a 0.5-1.5 MED dose of UV light. Another part of the study involves performing skin biopsies. One will be done prior to UVB exposure, 2 will be done at 24 hours and 2 more will be done at 48 hours.


Criteria:

Inclusion Criteria: - The subjects will be normal adult volunteers who are 18 to 65 years of age. Exclusion Criteria: - Subjects who drink more than two cups of coffee, tea, or caffeinated soda/beverages per day. - Subjects who are unable to get an erythemic response (i.e., a sunburn).


NCT ID:

NCT00134381


Primary Contact:

Principal Investigator
Melissa Magliocco, MD
Rutgers, The State University of New Jersey


Backup Contact:

N/A


Location Contact:

New Brunswick, New Jersey 08901
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

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