The Vietnam Head Injury Study (VHIS)-Phase III is a prospective, long-term follow-up study
of head-injured Vietnam veterans. The purpose of this research study is to determine the
long-term consequences, if any, of head injury.
The VHIS - Phase III evaluation to be conducted approximately 30 years post-injury will be
devoted to examining, cutting-edge cognitive neuroscience issues and will utilize state of
the art technologies to address basic research questions in the following areas: (1)
Functions of the human prefrontal cortex; (2) Cognitive neuroplasticity in the aging brain;
(3) Memory; (4) Long-term behavioral and psychosocial outcome; and (5) Neurological studies,
including an evaluation of post-traumatic epilepsy and repeat clinical measures from Phase -
II. This testing will be complemented with structural neuroimaging, electroencephalogram
(EEG) and molecular genetics. The goals of the VHIS - Phase III include providing clinicians
and scientists new insights into the long term recovery of function following brain injury,
the role of the prefrontal cortex in executive functions, better predictors of long term
outcome (including cognitive, neurological, and genetic factors), and the effects of head
injury incurred in youth on aging and the development of dementia.
The researchers are seeking healthy CONTROL participants.
- Vietnam Veteran
- Served in active combat between 1966 - 1971
- Any medical condition that would make participation detrimental to the control (i.e.:
severe clinical depression, acute heart dysfunction, etc...)
- A history of severe head injury, stroke, loss of consciousness, or other significant
neurological, psychiatric or medical condition that would render the subject
unsuitable for the VHIS testing battery.
Jordan Grafman, PhD
Cognitive Neuroscience Section, NINDS, NIH