Expired Study
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Pittsburgh, Pennsylvania 15213


Purpose:

The purpose of this research study is to determine whether a short-term administration of an investigational study drug may provide evidence of improvement in cognitive functioning in a group of stable male subjects with schizophrenia.


Study summary:

The goal of this study is to determine whether the short-term (4 week), double-blind administration of Merck L-830982 provides evidence of improvement in cognitive functioning in stable male subjects with schizophrenia. This initial, small sample size study (n=9 on L-830982 and n=6 on placebo) is restricted to males in order to reduce the variance that might be attributable to the well-documented sex differences in the clinical features of schizophrenia.


Criteria:

Inclusion Criteria: - Male participants - Between the ages of 18 and 50 - Meet diagnostic criteria for schizophrenia or schizoaffective disorder - Are clinically stable for a minimum of 3 months on current dose of medication - Are unemployed (i.e., work less than 20 hours per week at competitive employment) Exclusion Criteria: - Psychoactive substance dependence within the past 6 months or substance abuse within the past month - History of head trauma or other neurological disorder - Medical illness or medications, such as benzodiazepine treatment or HIV medications, that may be affected by study participation (the study doctor will discuss this with potential subjects) - Mental retardation - Seizure disorder - History of a heart attack, arrhythmia, or other heart disease


NCT ID:

NCT00129441


Primary Contact:

Principal Investigator
David A Lewis, MD
University of Pittsburgh


Backup Contact:

N/A


Location Contact:

Pittsburgh, Pennsylvania 15213
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: December 10, 2017

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