Patients who receive radiation therapy often have fatigue or a decrease in feeling well
causing a "wasting" away. For patients with advanced disease of lung cancer, prostate
cancer, or cancer that has spread to the bone, it is hoped that this drug may decrease this.
If patients feel better during treatments they can complete the therapy without any breaks
in treatment. For treatment to be most effective, it should be given in the amount needed,
on a particular schedule.
Subjects will be placed in a group to receive either the drug enbrel, or a placebo. The
radiation therapy treatments are as they would be given if the person was not on a research
study. The selection of the group a patient is in is done by random, like flipping a coin.
The doctor is not able to influence which group anyone is selected for. As is done
routinely, radiation therapy is given Monday through Friday for about 4 to 6 weeks.The
injections of enbrel or placebo are given two times a week. The enbrel or placebo is given
as an injection directly under the skin with a small needle.
- Advanced lung, prostate, or bony metastasis for cancer
- Performance status (PS) of 3 or less
- Good lab test results with albumin of at least 2.5
- Radiation therapy of at least 4000Gy in 4 weeks
- Poor PS
- Planned radiation therapy for less than 4 weeks or 4000Gy
- Limited disease
Charles R Thomas, Jr, MD
U Texas Health Science Center San Antonio
Cecelia Simmons, RN, CCRC