The purpose of this study is to compare the ability of low calorie high carbohydrate and low
calorie high fat/protein diets to decrease abdominal fat in overweight and obese subjects.
The investigators will also test the effects of these diets on secondary outcomes including
body composition, fluid and electrolyte balance, lipids and lipoproteins, blood pressure,
arterial compliance, glucose and insulin metabolism, bone turnover, and measures of satiety.
Participation in this study requires 2 screening visits to the outpatient clinic, and if
participants qualify, 10 inpatient study weeks.
Subjects will be admitted to the Rockefeller University Hospital for the 10 week in-patient
phase of the study. The first 2 weeks consist of a weight stabilization period, during which
subjects will be required to consume an average American diet. This is followed by the 6
week weight loss period where subjects will be randomized to either a low calorie high
carbohydrate or a low calorie high fat/protein diet. On both diets there will be a 50%
calorie deficit compared to the weight stabilization period. This will be followed by a 2
week weight maintenance period during which calories will be added to the diet to maintain
the new weight. Appropriate adjustments will be made to keep the subject's weight stable.
During the entire inpatient study, subjects will consume one multivitamin per day (Centrum,
always complete, from A to Zinc) and one iron supplement per day. In addition, unlimited
access to zero calorie liquids (water/diet soda) will be available and will be encouraged to
maintain one's usual activity level.
Females of reproductive age, need to make sure that they do not become pregnant during the
inpatient study. Urine will be tested for pregnancy once during the stabilization and weight
maintenance phases of the study.
- Man or a woman with a body mass index (BMI) of 30 to 34.9
- Man with a BMI of 25 to 29.9 with a waist circumference > 102cm (40in)
- Woman with a BMI of 25 to 29.9 with a waist circumference > 88cm (35in)
- High Blood Pressure
- High Cholesterol
- HIV positive
- Hepatitis B/C positive