Expired Study
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Seattle, Washington 98195


Purpose:

Surgery initiates a complex cascade of events involving the release of chemical compounds from nerve endings and damaged tissue which leads to an inflammatory and pain response. The purpose of this investigation is to measure various chemical mediators in the blood and cerebrospinal fluid, and to test the hypothesis that they will be decreased in patients treated with a COX-2 inhibitor.


Study summary:

Surgery initiates a complex cascade of events involving the release of nociceptive compounds from nerve endings and damaged tissue which leads to an inflammatory and hyperalgesic response. COX-2 inhibitors are often used for treating pain. This is a double-blind randomized study in surgical patients receiving a spinal drain for surgical purposes. The hypothesis is that valdecoxib will reach therapeutic concentrations in CSF, and will decrease plasma and CSF concentrations of inflammatory mediators. Subjects will receive valdecoxib 40 mg or placebo approximately 1 hr prior to surgery. Serial blood and CSF samples will be obtained. Valdecoxib and cytokine concentrations will be measured.


Criteria:

Inclusion Criteria: - Patients undergoing surgery requiring lumbar drain placement Exclusion Criteria: - Contraindication to COX-2 inhibitor (renal or hepatic insufficiency) - Known adverse reaction to nonsteroidal anti-inflammatory drugs (NSAIDs) - Use of NSAID or COX-2 within 7 days prior to surgery


NCT ID:

NCT00122096


Primary Contact:

Principal Investigator
Evan Kharasch, MD PhD
Washington University School of Medicine


Backup Contact:

N/A


Location Contact:

Seattle, Washington 98195
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: December 10, 2017

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