The purpose of this study is to evaluate levels of inflammatory mediators in children at
risk for cardiovascular disease due to family history. We are measuring inflammatory
markers in two groups of children and their parents: children with a family history of early
atherosclerotic heart disease (cases), and healthy children without such a family history
(controls). The design is a cross-sectional study, gathering a fasting blood sample and
clinical and behavioral data on children and a parent.
Family history is a well known risk factor for early atherosclerosis. Whether inflammation
plays a role in the increased risk of family history is not known. In this prospective
single-center study, we are recruiting children with and without a family history of
premature atherosclerotic disease, defined as occurring < 55 years in males and <65 years in
females. Children are recruited primarily from a pediatric preventive cardiology clinic at
Children's Hospital Boston. We measure anthropomorphic characteristics, fasting lipid
profiles and inflammatory marker levels, including high sensitivity C-reactive protein
(hsCRP), intracellular adhesion molecule 1 (ICAM-1), P-selectin, and tumor necrosis factor
alpha receptor 2 (TNFαR2).
In this sample of high-risk overweight children, Lp(a) and inflammatory markers could
reflect cardiovascular risk outside lipid profiles.
- Age 8-21 years
- Parent able to participate
- Fasting state
- Live locally
- Taking medication that may alter cholesterol levels or inflammatory state
- Past or present inflammatory illnesses