The purpose of this study is to see which of the two most common drugs used to treat
bronchiolitis works better. A child's participation in this study is expected to last less
than 4 hours. Approximately 600 patients will be recruited to participate in this study at
Kern Medical Center (KMC).
Bronchiolitis is a very common lung infection in babies. There are many drugs used to treat
this disease but nobody knows which one, if any, works the best. Two of the most commonly
used drugs are albuterol and epinephrine. These are both drugs given during breathing
treatments with oxygen and a mask. We are doing this study to see which of these drugs
works better or if they are both equally good. The study works as follows: after the consent
process the baby gets three treatments.
- Nebulizer 1 (Treatment)
- Treatment + 30 minutes (approximately) Nebulizer 2
- Treatment + 60 minutes (approximately) Nebulizer 3
- Treatment + 120 minutes (approximately)
The baby will be reevaluated and either discharged home or revert to standard therapy.
If the baby is discharged directly from the emergency department (E.D.), we will call you in
three days time to see how he/she is doing.
Double blind RCT. Primary outcome measure is admission defined as actual admission or
discharge with unscheduled return leading to admission within 72 hours. Secondary endpoints
include change in severity of illness and response of respiratory parameters to treatment.
- A clinical diagnosis of bronchiolitis
- Age greater than 18 months
- Disease too mild to warrant any treatment
- Emergent intubation on arrival at the ED
- Participation within another study within 30 days
- Refusal of informed parental consent
Paul Walsh, Paul Walsh, MD MSc(peds)
Kern Medical Center, David Geffen School of Medicine, UCLA