The purpose of this study is to determine the effectiveness of the herb sage in improving
the mental function of individuals with Alzheimer's disease.
Study hypothesis: The administration of sage will improve cognitive function in patients
with mild Alzheimer's disease.
The herb sage has been shown to enhance memory and mental function in healthy, young adults.
However, studies assessing the herb's effectiveness in older adults with symptoms of
Alzheimer's disease are limited. This study will determine the effect of sage extract on the
cognitive function of patients with mild Alzheimer's disease.
This study will last 6 weeks and will comprise 4 study visits, approximately 10 days apart.
Participants will be randomly assigned to receive either sage pills or no treatment during
each 10-day period. The treatment assignments will be switched in 10-day intervals, so that
during the course of the study, each participant will undergo two periods of sage treatment
and two periods without treatment. At each study visit, participants will undergo cognitive
testing, including tests to determine attention, memory, and visual cognition. Participants
will also undergo an electroencephalogram (EEG) and an electrocardiogram (ECG) at each
- Diagnosis of mild Alzheimer's disease
- Partner, friend, child, spouse, or relative willing to accompany participants to all
study visits, provide informed consent, monitor participants' pill-taking, and
communicate changes in participants' health during the study
- Significant medical illness other than Alzheimer's disease