The purpose of this study is to understand the factors that lead to muscle weakness with
arthritis and aging.
Through this study, we hope to learn about the natural history of knee osteoarthritis and
the disability that arises from it. We hope to better understand why people with knee
osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding
This study requires 1 four-hour visit to Harbor Hospital. The visit involves a physical
exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a
surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be
collected during your planned surgery.
Participation in this study is entirely voluntary.
- 50 years of age or older
- Normal body weight (a Body Mass Index (BMI) of 30 or less)
- Osteoarthritis of the knee (prior to knee surgery)
- Planning to have knee surgery at a MedStar Hospital
- History of a stroke
- History of muscle weakness or paralysis
- History of Rheumatoid Arthritis or
- Inflammatory Joint Disease
- History of a Bleeding Disorder
- History of Gout
- Diabetes for which you take insulin
- Polymyalgia rheumatica (total body muscle aching/stiffness)
Shari Ling, MD
NIA, Johns Hopkins Medical Institution Divisions of Rheumatology, Gerontology, and Geriatrics