The study compares the effectiveness of two fully approved shock waveforms (monophasic and
biphasic shock) commonly used to defibrillate (shock) patients with out-of-hospital cardiac
arrest due to a highly lethal rhythm problem (ventricular fibrillation). The purpose of the
study (hypothesis) is to determine if one waveform results in improved resuscitation,
admission alive to hospital, and discharge alive from hospital compared with the other.
The trial is designed to determine whether two fully-FDA-approved, commercially available
transthoracic defibrillation shock waveforms at comparable energies result in improved
patient outcome following out-of-hospital cardiac arrest due to ventricular fibrillation.
Eligible subjects include all adults with nontraumatic out-of-hospital cardiac arrest due to
ventricular fibrillation. Subjects in cardiac arrest will be randomly allocated to receive
one of two types of defibrillation shocks (monophasic or biphasic waveform) during their
resuscitation, which will in addition include all other standard treatments. The primary
endpoint is admission alive to hospital. Secondary endpoints include rhythm after
defibrillation shock, return of spontaneous circulation, and hospital discharge rates.
- Adult victims of nontraumatic out-of-hospital cardiac arrest due to ventricular