The purpose of this study is to determine if a certain medication, alone or combined with
another medication, will increase muscle activity in the upper airway in people who do and
people who do not have sleep apnea. The medications being studied are paroxetine, a
commonly used antidepressant, and 5 hydroxy-tryptophan (5HTP), which also can be used as a
dietary supplement without a prescription. Because the effects of paroxetine in previous
studies were not very large, we will also study it combined with 5HTP to see if the effect
on the upper airway muscles is greater.
Group A: 20 Adult patients with mild to severe sleep apnea. If patients are being
treated with nasal CPAP, they will continue treatment except on study nights.
Group B: 20 normal adult non-snoring subjects.