The purpose of this study is to determine whether DHEA replacement therapy decreases
abdominal fat and improves insulin sensitivity.
Studies on rats and mice have shown that the adrenal hormone dehydroepiandrosterone (DHEA)
reduces abdominal visceral fat and protects against insulin resistance. This study was done
to learn if DHEA replacement therapy decreases abdominal obesity and improves insulin action
Participants were randomly assigned to receive 50 mg per day of DHEA or a placebo at bedtime
for 6 months. Participants underwent magnetic resonance imaging (MRI) and oral glucose
tolerance tests at the beginning and conclusion of the study. Other tests included
measurements of hormones and lipids.
- 65 to 78 years old
- Physically healthy
- On stable medications for at least 6 months
- Stable body weight for the past year
- Serious active medical problems
- Hormone therapy
- Abnormal PSA (prostate specific antigen) in men