This study will determine the effectiveness of adding S-adenosyl methionine to
antidepressant drug treatment in reducing depressive symptoms in depressed people who have
not responded to antidepressants alone.
Some people with depression do not respond well to antidepressant treatment. S-adenosyl
methionine (SAMe) is a naturally occurring compound that may have antidepressant effects.
SAMe may also enhance the effectiveness of other antidepressants, such as selective
serotonin reuptake inhibitors (SSRIs). This study will determine the effectiveness of oral
SAMe in enhancing the effects of SSRIs in patients currently not responding to SSRI
This study will last 6 weeks. No follow-up visits will occur. Participants will be randomly
assigned to add either oral SAMe or placebo to their existing SSRI regimen for 6 weeks.
Depression scales and self-report questionnaires regarding depressive symptoms will be used
to assess participants at the end of the study.
- Major depressive disorder
- Use of an SSRI for at least 6 weeks prior to study entry with partial or no response
- History of psychosis
- Allergy to SAMe
- Alcohol or drug abuse in the past 3 months prior to study entry