The purpose of this study is to evaluate the extended pharmacological and psychological
treatment for chronic cigarette smokers.
The work adapts interventions that have been successful in the general populations, and
tailors them to chronic smokers, who may have numerous previous smoking treatment failures.
If successful it will: (1) make available a treatment intervention that produces hight long
term abstinence rates; (2) provide information on variables that predicts success and
failure in this population of smokers; (3) examine the cost-effectiveness of more intensive,
longer term treatments.
Subjects (N=400) will be men and women (50%) over the age of 18 who smoke at least 10
cigarettes per day and answers yes to the question "Do you smoke within 30 minutes of
-Subjects are age 18 and over, currently smoking 10 or more cigarettes per day, and report
a smoking history of at least 5 years in response to the question "How long have you been
a regular smoker?"
- History of seizure or head injury resulting in unconsciousness
- Any condition that might predispose to seizures (brain tumor or stroke)
- A current or history of anorexia nervosa or bulimia
- Any disease acutely life-threatening or so severe that the patient is judged unable
to comply with the protocol
- Use of a protease inhibitor of MAO inhibitor within the last two week
- Current use of psychiatric drugs that would interfere with interpretation of study
results, including antidepressants
- Treatment for alcohol dependence during the last year, or evidence of alcohol abuse
so severe that the patient is judged potentially unable to comply with the protocol
- Patients who know they are leaving the Bay Area within the study period and
non-English speakers will be excluded
- Suicidal or homicidal ideation
- Current major depression
- History of bipolar disorder
- Recent (within twelve months) myocardial infarction
- Any other medical condition that would contraindicate use of NRT or bupropion
- Physical limitation so severe that participation in a program of moderate exercise is
- Pregnancy or lactation