Expired Study
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San Francisco, California 94143


The purpose of this study is to evaluate the extended pharmacological and psychological treatment for chronic cigarette smokers.

Study summary:

The work adapts interventions that have been successful in the general populations, and tailors them to chronic smokers, who may have numerous previous smoking treatment failures. If successful it will: (1) make available a treatment intervention that produces hight long term abstinence rates; (2) provide information on variables that predicts success and failure in this population of smokers; (3) examine the cost-effectiveness of more intensive, longer term treatments.


Subjects (N=400) will be men and women (50%) over the age of 18 who smoke at least 10 cigarettes per day and answers yes to the question "Do you smoke within 30 minutes of arising?" Inclusion Criteria: -Subjects are age 18 and over, currently smoking 10 or more cigarettes per day, and report a smoking history of at least 5 years in response to the question "How long have you been a regular smoker?" Exclusion Criteria: - History of seizure or head injury resulting in unconsciousness - Any condition that might predispose to seizures (brain tumor or stroke) - A current or history of anorexia nervosa or bulimia - Any disease acutely life-threatening or so severe that the patient is judged unable to comply with the protocol - Use of a protease inhibitor of MAO inhibitor within the last two week - Current use of psychiatric drugs that would interfere with interpretation of study results, including antidepressants - Treatment for alcohol dependence during the last year, or evidence of alcohol abuse so severe that the patient is judged potentially unable to comply with the protocol - Patients who know they are leaving the Bay Area within the study period and non-English speakers will be excluded - Suicidal or homicidal ideation - Current major depression - History of bipolar disorder - Recent (within twelve months) myocardial infarction - Any other medical condition that would contraindicate use of NRT or bupropion - Physical limitation so severe that participation in a program of moderate exercise is not possible - Pregnancy or lactation



Primary Contact:

Principal Investigator
Sharon M Hall, Ph.D.
University of California, San Francisco

Backup Contact:


Location Contact:

San Francisco, California 94143
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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